Evidence for network-based cortical thickness reductions in schizophrenia

CMJ Wannan; VL Cropley; MM Chakravarty; C Bousman; EP Ganella; JM Bruggemann; TW Weickert; CS Weickert; I Everall; P McGorry; D Velakoulis; SJ Wood; CF Bartholomeusz; C Pantelis; A Zalesky

Journal article

Evidence for network-based cortical thickness reductions in schizophrenia

CMJ Wannan, VL Cropley, MM Chakravarty, C Bousman, EP Ganella, JM Bruggemann, TW Weickert, CS Weickert, I Everall, P McGorry, D Velakoulis, SJ Wood, CF Bartholomeusz, C Pantelis, A Zalesky

American Journal of Psychiatry | AMER PSYCHIATRIC PUBLISHING, INC | Published : 2019

DOI: 10.1176/appi.ajp.2019.18040380

Abstract

Objective: Cortical thickness reductions in schizophrenia are irregularly distributed across multiple loci. The authors hypothesized that cortical connectivity networks would explain the distribution of cortical thickness reductions across the cortex, and, specifically, that cortico-cortical connectivity between loci with these reductions would be exceptionally strong and form an interconnected network. This hypothesis was tested in three cross-sectional schizophrenia cohorts: first-episode psychosis, chronic schizophrenia, and treatment-resistant schizophrenia. Methods: Structural brain images were acquired for 70 patients with first-episode psychosis, 153 patients with chronic schizophreni..

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University of Melbourne Researchers

Cassandra Wannan Author

Vanessa Cropley Author

Patrick McGorry Author

Dennis Velakoulis Author

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Grants

Awarded by Brain and Behavior Research Foundation

Funding Acknowledgements

Supported by the Cooperative Research Centre (CRC) for Mental Health, an Australian government initiative. Also supported by a CRC for Mental Health Ph.D. top-up scholarship to Dr. Ganella and C. Wannan; a New South Wales Australia Ministry of Health, Office of Health and Medical Research grant and National Health and Medical Research Council Principal Research Fellowship (1117079) to Prof. C.S. Weickert; a research grant from the University of Melbourne to Dr. Ganella; a National Health and Medical Research Council (NHMRC) Career Development Fellowship (1127700) and a Brain and Behavior Research Foundation (NARSAD) Young Investigator Award (20526) to Assoc. Prof. Bousman; an NHMRC Senior Principal Research Fellowship (628386, 1105825) to Prof. Pantelis; and an NHMRC Senior Research Fellowship (level B) to Assoc. Professor Zalesky (number 1136649)