HIV-1-Based Virus-like Particles that Morphologically Resemble Mature, Infectious HIV-1 Virions
Christopher A Gonelli, Georges Khoury, Rob J Center, Damian FJ Purcell
VIRUSES-BASEL | MDPI | Published : 2019
A prophylactic vaccine eliciting both broad neutralizing antibodies (bNAbs) to the HIV-1 envelope glycoprotein (Env) and strong T cell responses would be optimal for preventing HIV-1 transmissions. Replication incompetent HIV-1 virus-like particles (VLPs) offer the opportunity to present authentic-structured, virion-associated Env to elicit bNAbs, and also stimulate T cell responses. Here, we optimize our DNA vaccine plasmids as VLP expression vectors for efficient Env incorporation and budding. The original vector that was used in human trials inefficiently produced VLPs, but maximized safety by inactivating RNA genome packaging, enzyme functions that are required for integration into the h..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
This research was funded by the National Health and Medical Research Council (NHMRC) of Australia Horizons 2020 grant APP1115828 and program grant APP1052979, and a project grant from ACH2 to D.F.J.P.