Journal article

Sex-specific spatial memory deficits in mice with a conditional TrkB deletion on parvalbumin interneurons

Adrienne Mary Grech, Xin Du, Simon S Murray, Junhua Xiao, Rachel Anne Hill

Behavioural Brain Research | ELSEVIER | Published : 2019

Abstract

Schizophrenia is a debilitating disorder characterised by three main symptom categories: positive, negative and cognitive. Cognitive symptoms emerge first, and currently do not have appropriate treatments, despite being a strong predictor of the severity and progress of the illness. Cognitive deficits are strongly associated with the dysfunction of GABAergic parvalbumin interneurons (PV-IN). PV-IN are supported by Brain-Derived Neurotrophic Factor (BDNF) via its receptor Tropomyosin-related Kinase B (TrkB). The main aim of this study was to investigate the cognitive and affective consequences of disrupted BDNF-TrkB signalling at PV-IN. We crossed PV-Cre mice with heterozygous TrkB floxed mic..

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University of Melbourne Researchers