Sex-specific spatial memory deficits in mice with a conditional TrkB deletion on parvalbumin interneurons
Adrienne Mary Grech, Xin Du, Simon S Murray, Junhua Xiao, Rachel Anne Hill
BEHAVIOURAL BRAIN RESEARCH | ELSEVIER | Published : 2019
Schizophrenia is a debilitating disorder characterised by three main symptom categories: positive, negative and cognitive. Cognitive symptoms emerge first, and currently do not have appropriate treatments, despite being a strong predictor of the severity and progress of the illness. Cognitive deficits are strongly associated with the dysfunction of GABAergic parvalbumin interneurons (PV-IN). PV-IN are supported by Brain-Derived Neurotrophic Factor (BDNF) via its receptor Tropomyosin-related Kinase B (TrkB). The main aim of this study was to investigate the cognitive and affective consequences of disrupted BDNF-TrkB signalling at PV-IN. We crossed PV-Cre mice with heterozygous TrkB floxed mic..View full abstract
Awarded by NHMRC/ARC
Awarded by National Health and Medical Research Council
This work was supported by an NHMRC/ARC dementia fellowship by Dr Xin Du (1109959). R.A.H. is supported by a National Health and Medical Research Council Career Development (R.D. Wright) Fellowship (1062826).