Treadmill Exercise before and during Pregnancy Improves Bone Deficits in Pregnant Growth Restricted Rats without the Exacerbated Effects of High Fat Diet
Kristina Anevska, Dayana Mahizir, Jessica E Briffa, Andrew J Jefferies, John D Wark, Brian L Grills, Rhys D Brady, Stuart J McDonald, Mary E Wlodek, Tania Romano
NUTRIENTS | MDPI | Published : 2019
Growth restriction programs adult bone deficits and increases the risk of obesity, which may be exacerbated during pregnancy. We aimed to determine if high-fat feeding could exacerbate the bone deficits in pregnant growth restricted dams, and whether treadmill exercise would attenuate these deficits. Uteroplacental insufficiency was induced on embryonic day 18 (E18) in Wistar Kyoto (WKY) rats using bilateral uterine vessel ligation (restricted) or sham (control) surgery. The F1 females consumed a standard or high-fat (HFD) diet from 5 weeks, commenced treadmill exercise at 16 weeks, and they were mated at 20 weeks. Femora and plasma from the pregnant dams were collected at post-mortem (E20) ..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
This research was funded by the Diabetes Australia Research Trust awarded to M. E. Wlodek, and the National Health and Medical Research Council (NHMRC) of Australia (APP1025426) and (APP1045602) awarded to M. E. Wlodek. D. Mahizir received support from the Majlis Amanah Rakyat (MARA) Malaysian Government Agency. K. Anevska received support through the La Trobe University Postgraduate Research Scholarship. J.F. Briffa holds an MDHS Faculty Fellowship at the University of Melbourne.