Could an Impairment in Local Translation of mRNAs in Glia be Contributing to Pathogenesis in ALS?
Samantha K Barton, Jenna M Gregory, Siddharthan Chandran, Bradley J Turner
FRONTIERS IN MOLECULAR NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2019
One of the key pathways implicated in amyotrophic lateral sclerosis (ALS) pathogenesis is abnormal RNA processing. Studies to date have focussed on defects in RNA stability, splicing, and translation, but this review article will focus on the largely overlooked RNA processing mechanism of RNA trafficking, with particular emphasis on the importance of glia. In the central nervous system (CNS), oligodendrocytes can extend processes to myelinate and metabolically support up to 50 axons and astrocytes can extend processes to cover up to 100,000 synapses, all with differing local functional requirements. Furthermore, many of the proteins required in these processes are large, aggregation-prone pr..View full abstract
Awarded by National Health and Medical Research Council
SB (APP1110040) and BT (APP1137024) received support from National Health and Medical Research Council and Australian Research Council fellowships.