Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype

Lisa Vermunt; Sietske AM Sikkes; Ardo van den Hout; Ron Handels; Isabelle Bos; Wiesje M van der Flier; Silke Kern; Pierre-Jean Ousset; Paul Maruff; Ingmar Skoog; Frans RJ Verhey; Yvonne Freund-Levi; Magda Tsolaki; Asa K Wallin; Marcel Olde Rikkert; Hilkka Soininen; Luisa Spiru; Henrik Zetterberg; Kaj Blennow; Philip Scheltens; Graciela Muniz-Terrera; Pieter Jelle Visser; B Vellas; E Reynish; PJ Ousset; S Andrieu; A Burns; F Pasquier; G Frisoni; E Salmon; JP Michel; DS Zekry; M Boada; JF Dartigues; MGM Olde-Rikkert; AS Rigaud; B Winblad; A Malick; A Sinclair; L Froelich; P Scheltens; C Ribera; J Touchon; P Robert; A Salva; G Waldemar; R Bullock; M Tsolaki; G Rodriguez; L Spiru; RW Jones; G Stiens; G Stoppe; Eriksdotter M Jonhagen; A Cherubini; PM Lage; T Gomezisla; V Camus; E Aguera-Morales; F Lopez; S Savy; C Cantet; N Coley

Journal article

Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype

Lisa Vermunt, Sietske AM Sikkes, Ardo van den Hout, Ron Handels, Isabelle Bos, Wiesje M van der Flier, Silke Kern, Pierre-Jean Ousset, Paul Maruff, Ingmar Skoog, Frans RJ Verhey, Yvonne Freund-Levi, Magda Tsolaki, Asa K Wallin, Marcel Olde Rikkert, Hilkka Soininen, Luisa Spiru, Henrik Zetterberg, Kaj Blennow, Philip Scheltens Show all

Alzheimer's & Dementia | ELSEVIER SCIENCE INC | Published : 2019

DOI: 10.1016/j.jalz.2019.04.001

Abstract

INTRODUCTION: We estimated the age-specific duration of the preclinical, prodromal, and dementia stages of Alzheimer's disease (AD) and the influence of sex, setting, apolipoprotein E (APOE) genotype, and cerebrospinal fluid tau on disease duration. METHODS: We performed multistate modeling in a combined sample of 6 cohorts (n = 3268) with death as the end stage and estimated the preclinical, prodromal, and dementia stage duration. RESULTS: The overall AD duration varied between 24 years (age 60) and 15 years (age 80). For individuals presenting with preclinical AD, age 70, the estimated preclinical AD duration was 10 years, prodromal AD 4 years, and dementia 6 years. Male sex, clinical sett..

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