Journal article

Immune checkpoint inhibitors for patients with advanced lung cancer and oncogenic driver alterations: results from the IMMUNOTARGET registry

J Mazieres, A Drilon, A Lusque, L Mhanna, AB Cortot, L Mezquita, AA Thai, C Mascaux, S Couraud, R Veillon, M Van Den Heuvel, J Neal, N Peled, M Fruh, TL Ng, V Gounant, S Popat, J Diebold, J Sabari, VW Zhu Show all

Annals of Oncology | OXFORD UNIV PRESS | Published : 2019

Abstract

BACKGROUND: Anti-PD1/PD-L1 directed immune-checkpoint-inhibitors (ICI) are widely used to treat patients with advanced non-small cell lung cancer (NSCLC). The activity of ICI across NSCLC harboring oncogenic alterations is poorly characterized. The aim of our study was to address the efficacy of ICI in the context of oncogenic addiction. PATIENTS AND METHODS: We conducted a retrospective study for patients receiving ICI monotherapy for advanced NSCLC with at least one oncogenic driver alteration. Anonymized data were evaluated for clinicopathologic characteristics and outcomes for ICI therapy: best response (RECIST 1.1), progression-free survival (PFS) and overall survival (OS) from ICI init..

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