Journal article
The potential of carnosine in brain-related disorders: A comprehensive review of current evidence
M Schön, A Mousa, M Berk, WL Chia, J Ukropec, A Majid, B Ukropcová, B De Courten
Nutrients | MDPI | Published : 2019
DOI: 10.3390/nu11061196
Abstract
Neurological, neurodegenerative, and psychiatric disorders represent a serious burden because of their increasing prevalence, risk of disability, and the lack of effective causal/disease-modifying treatments. There is a growing body of evidence indicating potentially favourable effects of carnosine, which is an over-the-counter food supplement, in peripheral tissues. Although most studies to date have focused on the role of carnosine in metabolic and cardiovascular disorders, the physiological presence of this di-peptide and its analogues in the brain together with their ability to cross the blood-brain barrier as well as evidence from in vitro, animal, and human studies suggest carnosine as..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This research received funding by SAIA (Slovak Academic Information Agency), which supported the short-term scientific mission of M.S. on Monash University. A. Mousa is supported by a Peter Doherty Biomedical Research fellowship provided by the National Health and Medical Research Council (NHMRC) of Australia. A National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (APP1059660 and APP1156072) supported M.B. APVV 15-0253, VEGA 2/0107/18 and SAS-MOST JRP 2018/10 supported B.U. and J.U. The NIHR Sheffield Biomedical Research Centre (BRC)/NIHR Sheffield Clinical Research Facility (CRF) partially supported A. Majid. A National Heart Foundation Future Leader Fellowship (100864) supported B.d.C.