Journal article

External validation of the US and UK kidney donor risk indices for deceased donor kidney transplant survival in the Australian and New Zealand population

Philip A Clayton, Kathryn Dansie, Matthew P Sypek, Sarah White, Steve Chadban, John Kanellis, Peter Hughes, Aarti Gulyani, Stephen McDonald



BACKGROUND: The US Kidney Donor Risk Index (KDRI) and the UK KDRI were developed to estimate the risk of graft failure following kidney transplantation. Neither score has been validated in the Australian and New Zealand (ANZ) population. METHODS: Using data from the Australia and New Zealand Organ Donor (ANZOD) and Dialysis and Transplant (ANZDATA) Registries, we included all adult deceased donor kidney-only transplants performed in ANZ from 2005 to 2016 (n = 6405). The KDRI was calculated using both the US donor-only and UK formulae. Three Cox models were constructed (Model 1: KDRI only; Model 2: Model 1 + transplant characteristics; Model 3: Model 2 + recipient characteristics) and compare..

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Funding Acknowledgements

The ANZDATA Registry is funded by the Australian Organ and Tissue Donation and Transplantation Authority, the NZ Ministry of Health and Kidney Health Australia. P.A.C., K.D. and A.G. are supported by a Better Evidence and Translation in Chronic Kidney Disease (BEAT-CKD) Program Grant (Australian National Health and Medical Research Council).