Furosemide reverses medullary tissue hypoxia in ovine septic acute kidney injury
Naoya Iguchi, Yugeesh R Lankadeva, Trevor A Mori, Eduardo A Osawa, Salvatore L Cutuli, Roger G Evans, Rinaldo Bellomo, Clive N May
AJP Regulatory Integrative and Comparative Physiology | AMER PHYSIOLOGICAL SOC | Published : 2019
In experimental sepsis, the rapid development of renal medullary hypoxia precedes the development of acute kidney injury (AKI) and may contribute to its pathogenesis. We investigated whether inhibiting active sodium transport and oxygen consumption in the medullary thick ascending limb with furosemide attenuates the medullary hypoxia in experimental septic AKI. Sheep were instrumented with flow probes on the pulmonary and renal arteries and fiber optic probes to measure renal cortical and medullary perfusion and oxygen tension (Po2). Sepsis and AKI were induced by infusion of live Escherichia coli. At 24 h of sepsis there were significant decreases in renal medullary tissue perfusion (1,332 ..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Awarded by National Heart Foundation of Australia
This study was supported by a grant from the National Health and Medical Research Council of Australia (1050672) and by funding from a Victorian Government Operational Infrastructure Support Grant. Y. R. Lankadeva was supported by Postdoctoral Fellowships by the National Heart Foundation of Australia (100869 and 101853).