Journal article

Sepsis uncouples serum C-peptide and insulin levels in critically ill patients with type 2 diabetes mellitus

Laurent Bitker, Salvatore L Cutuli, Luca Cioccari, Eduardo A Osawa, Lisa Toh, Nora Luethi, Helen Young, Leah Peck, Glenn M Eastwood, Johan Martensson, Rinaldo Bellomo

Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine | AUSTRALASIAN MED PUBL CO LTD | Published : 2019

Abstract

OBJECTIVE: To assess the effects of sepsis and exogenous insulin on C-peptide levels and C-peptide to insulin ratios in intensive care unit (ICU) patients with type 2 diabetes mellitus (T2DM). DESIGN, SETTING AND PARTICIPANTS: In this prospective, observational, single-centre study, we enrolled 31 ICU-admitted adults with T2DM. We measured serum C-peptide and insulin levels during the first 3 days of ICU stay and recorded characteristics of exogenous insulin therapy. Patients were compared on the basis of the presence of sepsis, and their exposure to exogenous insulin therapy. C-peptide levels were also measured in eight healthy subjects. MAIN OUTCOME MEASURES: Serum insulin and C-peptide le..

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University of Melbourne Researchers