Journal article

Catheter ablation versus medical therapy for treatment of ventricular tachycardia associated with structural heart disease: Systematic review and meta-analysis of randomized controlled trials and comparison with observational studies

Robert D Anderson, Nilshan Ariyarathna, Geoffrey Lee, Sohaib Virk, Ivana Trivic, Timothy Campbell, Clara K Chow, Jonathan Kalman, Saurabh Kumar

Heart Rhythm | ELSEVIER SCIENCE INC | Published : 2019


BACKGROUND: Catheter ablation (CA) is an established therapeutic modality for ventricular tachycardia (VT). OBJECTIVE: We compared the clinical outcomes of CA for VT vs medical therapy from all previously performed randomized controlled trials (RCTs) and compared these to contemporary observational studies. METHODS: A comprehensive database search through to August 2018 identified 8 eligible studies enrolling 797 patients. RESULTS: In RCTs, VT recurrence and electrical VT storm were significantly reduced in the CA group vs medical therapy group (relative risk [RR] 0.78, 95% confidence interval [CI] 0.64-0.95, P = .01; RR 0.70, 95% CI 0.51-0.94, P = .02, respectively) at a mean follow-up of 2..

View full abstract