Journal article

Increased cerebral blood flow with increased amyloid burden in the preclinical phase of alzheimer's disease

Amir Fazlollahi, Fernando Calamante, Xiaoyun Liang, Pierrick Bourgeat, Parnesh Raniga, Vincent Dore, Jurgen Fripp, David Ames, Colin L Masters, Christopher C Rowe, Alan Connelly, Victor L Villemagne, Olivier Salvado

Journal of Magnetic Resonance Imaging | WILEY | Published : 2020

Abstract

BACKGROUND: Arterial spin labeling (ASL) is an emerging MRI technique for noninvasive measurement of cerebral blood flow (CBF) that has been used to show hemodynamic changes in the brains of people with Alzheimer's disease (AD). CBF changes have been measured using positron emission tomography (PET) across the AD spectrum, but ASL showed limited success in measuring CBF variations in the preclinical phase of AD, where amyloid β (Aβ) plaques accumulate in the decades prior to symptom onset. PURPOSE: To investigate the relationship between CBF measured by multiphase-pseudocontinuous-ASL (MP-PCASL) and Aβ burden as measured by 11 C-PiB PET imaging in a study of cognitively normal (CN) subjects ..

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