Journal article

A Plasmodium Cross-Stage Antigen Contributes to the Development of Experimental Cerebral Malaria

Priyanka Fernandes, Shanshan W Howland, Kirsten Heiss, Angelika Hoffmann, Maria A Hernandez-Castaneda, Klara Obrova, Roland Frank, Philipp Wiedemann, Martin Bendzus, Laurent Renia, Ann-Kristin Mueller

FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2018

Abstract

Cerebral malaria is a complex neurological syndrome caused by an infection with Plasmodium falciparum parasites and is exclusively attributed to a series of host-parasite interactions at the pathological blood-stage of infection. In contrast, the preceding intra-hepatic phase of replication is generally considered clinically silent and thereby excluded from playing any role in the development of neurological symptoms. In this study, however, we present an antigen PbmaLS_05 that is presented to the host immune system by both pre-erythrocytic and intra-erythrocytic stages and contributes to the development of cerebral malaria in mice. Although deletion of the endogenous PbmaLS_05 prevented the..

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University of Melbourne Researchers

Grants

Awarded by German research foundation (DFG)


Funding Acknowledgements

PF and this work were funded through the LGFG fellowship and an Innovative Fund Frontier Grant from the University of Heidelberg. This study was supported by the German research foundation (DFG) through SPP 1580 (to AKM) and SFB 1129 (to AKM). AKM is a recipient of a Maternity Leave stipend of the German Center for Infectious Diseases (DZIF). AH was supported by a post-doctoral fellowship of the University of Heidelberg. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.