Journal article

Dimethyl fumarate attenuates cerebral edema formation by protecting the blood-brain barrier integrity

Reiner Kunze, Andres Urrutia, Angelika Hoffmann, Hui Liu, Xavier Helluy, Mirko Pham, Stefan Reischl, Thomas Korff, Hugo H Marti

EXPERIMENTAL NEUROLOGY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2015

Abstract

Brain edema is a hallmark of various neuropathologies, but the underlying mechanisms are poorly understood. We aim to characterize how tissue hypoxia, together with oxidative stress and inflammation, leads to capillary dysfunction and breakdown of the blood-brain barrier (BBB). In a mouse stroke model we show that systemic treatment with dimethyl fumarate (DMF), an antioxidant drug clinically used for psoriasis and multiple sclerosis, significantly prevented edema formation in vivo. Indeed, DMF stabilized the BBB by preventing disruption of interendothelial tight junctions and gap formation, and decreased matrix metalloproteinase activity in brain tissue. In vitro, DMF directly sustained end..

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University of Melbourne Researchers