Do Microemboli Reach the Brain Penetrating Arteries?
Lei Zhu, Angelika Hoffmann, Max Wintermark, Xianmang Pan, Richard Tu, Joseph H Rapp
JOURNAL OF SURGICAL RESEARCH | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2012
BACKGROUND: As they are "end arteries," microembolic obstruction of brain penetrating arteries would be expected to create ischemia. Yet the mammalian brain appears to have an impressive tolerance to experimental microembolization with ischemia occurring only after the injection of large numbers of particulates. Potential explanations could be that the majority of these particulates marginate along the pial vasculature or escape the cerebral circulation via arteriovenous (AV) fistulae. METHODS: To test these theories, we first established the level of injury created by the injection of 20, 45, and 90 μm fluorescent microspheres in Sprague-Dawley rats. Brains were examined by immunohistochemi..View full abstract