Journal article

Apolipoprotein E Homozygous epsilon 4 Allele Status: A Deteriorating Effect on Visuospatial Working Memory and Global Brain Structure

Janik Goltermann, Ronny Redlich, Katharina Dohm, Dario Zaremba, Jonathan Repple, Claas Kaehler, Dominik Grotegerd, Katharina Foerster, Susanne Meinert, Verena Enneking, Emily Schlaghecken, Lara Fleischer, Tim Hahn, Harald Kugel, Andreas Jansen, Axel Krug, Katharina Brosch, Igor Nenadic, Simon Schmitt, Frederike Stein Show all

FRONTIERS IN NEUROLOGY | FRONTIERS MEDIA SA | Published : 2019

Abstract

Theoretical background: The Apolipoprotein E (APOE) ε4 genotype is known to be one of the strongest single-gene predictors for Alzheimer disease, which is characterized by widespread brain structural degeneration progressing along with cognitive impairment. The ε4 allele status has been associated with brain structural alterations and lower cognitive ability in non-demented subjects. However, it remains unclear to what extent the visuospatial cognitive domain is affected, from what age onward changes are detectable and if alterations may interact with cognitive deficits in major depressive disorder (MDD). The current work investigated the effect of APOE ε4 homozygosity on visuospatial workin..

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University of Melbourne Researchers

Grants

Awarded by German Research Council (Deutsche Forschungsgemeinschaft, DFG)


Awarded by German Research Foundation (DFG)


Awarded by Interdisciplinary Center for Clinical Research (IZKF) of the Medical Faculty of Munster


Funding Acknowledgements

The FOR 2107 consortium is supported by the German Research Council (Deutsche Forschungsgemeinschaft, DFG, Grant nos. KI 588/14-1, KI 588/14-2, KR 3822/7-1, KR 3822/7-2, NE 2254/1-2, DA 1151/5-1, DA 1151/5-2, SCHW559/14-1, 545/7-2, RI 908/11-2, WI 3439/3-2, NO 246/10-2, DE 1614/3-2, HA 7070/2-2, JA 1890/7-1, JA 1890/7-2, MU 1315/8-2, RE 737/20-2, KI 588/17-1).This work was furthermore funded by the German Research Foundation (DFG, grant FOR2107 DA1151/5-1 and DA1151/5-2 to UD; SFB-TRR58, Projects C09 and Z02 to UD) and the Interdisciplinary Center for Clinical Research (IZKF) of the Medical Faculty of Munster (grant Dan3/012/17 to UD).We further acknowledge support from the Open Access Publication Fund of the University of Munster.