Journal article

Peripheral Nerve Regeneration Is Independent From Schwann Cell p75(NTR) Expression

Nadia P Goncalves, Simin Mohseni, Marwa El Soury, Maj Ulrichsen, Mette Richner, Junhua Xiao, Rhiannon J Wood, Olav M Andersen, Elizabeth J Coulson, Stefania Raimondo, Simon S Murray, Christian B Vaegter

FRONTIERS IN CELLULAR NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2019

Abstract

Schwann cell reprogramming and differentiation are crucial prerequisites for neuronal regeneration and re-myelination to occur following injury to peripheral nerves. The neurotrophin receptor p75NTR has been identified as a positive modulator for Schwann cell myelination during development and implicated in promoting nerve regeneration after injury. However, most studies base this conclusion on results obtained from complete p75NTR knockout mouse models and cannot dissect the specific role of p75NTR expressed by Schwann cells. In this present study, a conditional knockout model selectively deleting p75NTR expression in Schwann cells was generated, where p75NTR expression is replaced with tha..

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Grants

Awarded by Aarhus University Research Foundation


Awarded by Novo Nordisk Foundation


Awarded by Australian National Health and Medical Research Council


Funding Acknowledgements

This work was supported by Aarhus University Research Foundation (AUFF-E-2015-FLS-8-4), a challenge grant from the Novo Nordisk Foundation (NNF14OC0011633), Dagmar Marshal's Fund, and the Australian National Health and Medical Research Council Project Grant #APP1058647.