Journal article

Quantifying ultrasonic mouse vocalizations using acoustic analysis in a supervised statistical machine learning framework

Adam P Vogel, Athanasios Tsanas, Maria Luisa Scattoni



Examination of rodent vocalizations in experimental conditions can yield valuable insights into how disease manifests and progresses over time. It can also be used as an index of social interest, motivation, emotional development or motor function depending on the animal model under investigation. Most mouse communication is produced in ultrasonic frequencies beyond human hearing. These ultrasonic vocalizations (USV) are typically described and evaluated using expert defined classification of the spectrographic appearance or simplistic acoustic metrics resulting in nine call types. In this study, we aimed to replicate the standard expert-defined call types of communicative vocal behavior in ..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council, Australia

Awarded by Italian Ministry of Health

Awarded by Wellcome Trust

Awarded by Health Data Research UK from HDR UK Ltd - UK Medical Research Council

Funding Acknowledgements

A.P.V.' s work was supported in part by the National Health and Medical Research Council, Australia (#1082910, Career Development Fellowship and a Dementia Fellowship #1135683), and by the Alexander von Humboldt Foundation. M.L.S. received funding from the Italian Ministry of Health Grant (GR-2010-2315883). A. T. was previously supported by the Wellcome Trust through a Centre Grant No. 098461/Z/12/Z, "The University of Oxford Sleep and Circadian Neuroscience Institute (SCNi)". The study was also supported by Health Data Research UK, which receives funding from HDR UK Ltd (HDR-5012) funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), the British Heart Foundation, and the Wellcome Trust. The funders had no role in the study or the decision to submit this work to be considered for publication. A.P.V. is Chief Science Officer of Redenlab P/L who undertake speech biomarker research services. A.T. and M.L.S. declare no competing financial interests.