Retinal degeneration rat model: A study on the structural and functional changes in the retina following injection of sodium iodate
Avin Ee-Hwan Koh, Hiba Amer Alsaeedi, Munirah Binti Abd Rashid, Chenshen Lam, Mohd Hairul Nizam Harun, Muhamad Fakhri bin Mohd Saleh, Chi D Luu, S Suresh Kumar, Min Hwei Ng, Hazlita Mohd Isa, Sue Ngein Leow, Kong Yong Then, Mae-Lynn Catherine Bastion, Mohammed Safwan Ali Khan, Pooi Ling Mok
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | ELSEVIER SCIENCE SA | Published : 2019
Retinal disorders account for a large proportion of ocular disorders that can lead to visual impairment or blindness, and yet our limited knowledge in the pathogenesis and choice of appropriate animal models for new treatment modalities may contribute to ineffective therapies. Although genetic in vivo models are favored, the variable expressivity and penetrance of these heterogeneous disorders can cause difficulties in assessing potential treatments against retinal degeneration. Hence, an attractive alternative is to develop a chemically-induced model that is both cost-friendly and standardizable. Sodium iodate is an oxidative chemical that is used to simulate late stage retinitis pigmentosa..View full abstract
Awarded by Ministry of Science, Technology, Environment & Climate Change (MESTECC), Malaysia through the Science Fund
This research was supported by the Ministry of Science, Technology, Environment & Climate Change (MESTECC), Malaysia through the Science Fund (Grant No.: 5450817).