Journal article

Genomic variation predicts adaptive evolutionary responses better than population bottleneck history

Michael Orsted, Ary Anthony Hoffmann, Elsa Sverrisdottir, Kare Lehmann Nielsen, Torsten Nygaard Kristensen



The relationship between population size, inbreeding, loss of genetic variation and evolutionary potential of fitness traits is still unresolved, and large-scale empirical studies testing theoretical expectations are surprisingly scarce. Here we present a highly replicated experimental evolution setup with 120 lines of Drosophila melanogaster having experienced inbreeding caused by low population size for a variable number of generations. Genetic variation in inbred lines and in outbred control lines was assessed by genotyping-by-sequencing (GBS) of pooled samples consisting of 15 males per line. All lines were reared on a novel stressful medium for 10 generations during which body mass, pro..

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University of Melbourne Researchers


Awarded by Danish Natural Science Research Council

Funding Acknowledgements

This research was supported by the Danish Natural Science Research Council (8021-00014B), the Australian Science Industry Endowment Fund and a grant from the Velux Visiting Professor programme. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.