Journal article

Genomic variation predicts adaptive evolutionary responses better than population bottleneck history

Michael Orsted, Ary Anthony Hoffmann, Elsa Sverrisdottir, Kare Lehmann Nielsen, Torsten Nygaard Kristensen

PLOS GENETICS | PUBLIC LIBRARY SCIENCE | Published : 2019

Abstract

The relationship between population size, inbreeding, loss of genetic variation and evolutionary potential of fitness traits is still unresolved, and large-scale empirical studies testing theoretical expectations are surprisingly scarce. Here we present a highly replicated experimental evolution setup with 120 lines of Drosophila melanogaster having experienced inbreeding caused by low population size for a variable number of generations. Genetic variation in inbred lines and in outbred control lines was assessed by genotyping-by-sequencing (GBS) of pooled samples consisting of 15 males per line. All lines were reared on a novel stressful medium for 10 generations during which body mass, pro..

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University of Melbourne Researchers

Grants

Awarded by Danish Natural Science Research Council


Funding Acknowledgements

This research was supported by the Danish Natural Science Research Council (8021-00014B), the Australian Science Industry Endowment Fund and a grant from the Velux Visiting Professor programme. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.