Conference Proceedings

Neural Stimulation with an Endovascular Brain-Machine Interface

NL Opie, SE John, G Gerboni, GS Rind, TJH Lovell, SM Ronayne, YT Wong, CN May, DB Grayden, TJ Oxley

2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) | IEEE | Published : 2019

Abstract

Stimulation of deep cortical structures has been demonstrated to provide symptomatic alleviation to people with depression, Parkinson's disease and epilepsy. However, electrodes used clinically for therapies requiring deep-brain-stimulation are currently limited to those that penetrate directly through delicate neural tissue following craniotomy or burr-hole surgery. Using an endovascular neural interface, the risks associated with open-brain surgery can be mitigated. Previously, we demonstrated proof-of-concept that a stent-electrode array can access the brain via blood vessels and can record high-fidelity neural information over a chronic duration. However, it was unknown whether focal sti..

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Grants

Awarded by US Defense Advanced Research Projects Agency (DARPA) Microsystems Technology Office


Awarded by Office of Naval Research (ONR) Global


Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by Office of the Assistant Secretary of Defense for Health Affairs, through the Spinal Cord Injury Program Translational Research Award


Funding Acknowledgements

Research was supported by US Defense Advanced Research Projects Agency (DARPA) Microsystems Technology Office contract N66001-12-1-4045; Office of Naval Research (ONR) Global N62909-141-1-N020; National Health and Medical Research Council of Australia (NHMRC) Project Grant APP1062532 and the Office of the Assistant Secretary of Defense for Health Affairs, through the Spinal Cord Injury Program Translational Research Award No. W81XWH-17-1-0210, and the Westpac Bicentennial Foundation.