Journal article
COQ10 and cognition a review and study protocol for a 90-day randomized controlled trial investigating the cognitive effects of ubiquinol in the healthy elderly
C Stough, M Nankivell, DA Camfield, NL Perry, A Pipingas, H Macpherson, K Wesnes, R Ou, D Hare, J De Haan, G Head, P Lansjoen, A Langsjoen, B Tan, MP Pase, R King, R Rowsell, O Zwalf, Y Rathner, M Cooke Show all
Frontiers in Aging Neuroscience | FRONTIERS MEDIA SA | Published : 2019
Abstract
Introduction: With an aging population there is an important need for the development of effective treatments for the amelioration of cognitive decline. Multiple mechanisms underlie age-related cognitive decline including cerebrovascular disease, oxidative stress, reduced antioxidant capacity and mitochondrial dysfunction. CoQ10 is a novel treatment which has the potential to improve brain function in healthy elderly populations due to established beneficial effects on mitochondrial function, vascular function and oxidative stress. Methods and Analysis: We describe the protocol for a 90-day randomized controlled trial which examines the efficacy of Ubiquinol (200 mg/day) vs. placebo for the ..
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Funding Acknowledgements
.The study described in this protocol was funded by Kaneka (Japan) in a grant to CS and FR. They approved the protocol which was developed and proposed by the authors of this protocol article. Under the contract, Kaneka cannot stop publication of the results of the proposed study. All analyses, interpretation and writing of the results of the study will be undertaken by the authors of this protocol article.