Maternal Loeys-Dietz syndrome (transforming growth factor ligand 2) in a twin pregnancy: Case report and discussion

Abstract

Loeys-Dietz syndrome is a rare autosomal dominant connective tissue disorder. Pregnant women with Loeys-Dietz syndrome are at increased risk of serious vascular and visceral complications, including aortic dissection and uterine rupture. Multidisciplinary tertiary management aims to mitigate such complications by preconception counselling and vascular assessment, medical therapy, regular echocardiography in pregnancy and joint decision-making re-mode and timing of delivery. We report an in vitro fertilisation twin pregnancy in a woman with Loeys-Dietz syndrome first seen at our institution at 26 weeks' gestation. After monitoring via serial echocardiograms, caesarean delivery occurred at 30 ..