Conference Proceedings
Joint genome-wide association study of endometrial cancer and ovarian cancer identifies a novel genetic risk region at 14q23.3
Tracy A O'Mara, Dylan M Glubb, Daniel D Buchanan, Diether Lambrechts, Per Hall, Emma Tham, Jone Trovik, Ellen L Goode, Peter Fasching, Thilo Doerk, Rodney J Scott, Paul L Auer, Roger L Milne, Graham G Giles, John Perry, Immaculata de Vivo, Ian Tomlinson, Douglas F Easton, Deborah J Thompson, Amanda B Spurdle
CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2018
Abstract
Abstract Ovarian cancer is the most lethal gynecologic malignancy and the sixth most common cause of death from all cancer in women, with an estimated 140,000 deaths per year worldwide. Endometrial cancer (cancer of the uterine lining) is the most commonly diagnosed gynecologic cancer, ranking sixth in incident cancer in women. Ovarian and endometrial cancer share many epidemiologic, histopathologic, and tumor genetic characteristics. Meta-analyses of genome-wide association study (GWAS) datasets across etiologically related diseases have successfully been used to increase statistical power and identify novel genetic risk regions. We hypothesised that joint meta-analysis of ov..
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