Book Chapter

Repurposed Molecules: A New Hope in Tackling Neglected Infectious Diseases

C Fernández-Prada, N Douanne, A Minguez-Menendez, J Pena, LG Tunes, DEV Pires, RL Monte-Neto, Kunal Roy

In Silico Drug Design: Repurposing Techniques and Methodologies | Elsevier | Published : 2019

Abstract

Neglected infectious diseases (NIDs) are a group of chronic, debilitating, and poverty-promoting diseases, which include parasitic, bacterial, viral, and fungal infections. Current treatments are far from optimal due to major limitations, ranging from high levels of drug toxicity to the emergence and spread of drug-resistant strains. In addition, drug discovery is presently a major obstacle in the control of these diseases. NIDs are a heterogeneous group of pathogens that have been traditionally abandoned in terms of funding and policy, leading to a sparse and obsolete pharmacopeia. In this chapter, we explore and discuss the current situation of NIDs globally, as well as different drug-repu..

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