Journal article

Otoacoustic emission amplification after inner hair cell damage

M Wake, J Anderson, S Takeno, RJ Mount, RV Harrison

ACTA OTO-LARYNGOLOGICA | SCANDINAVIAN UNIVERSITY PRESS | Published : 1996

Abstract

Otoacoustic emissions (OAEs) are considered to originate from active cochlear processes involving the outer hair cells (OHC). These emissions are suppressed by activity in the efferent olivocochlear bundle (OCB) and following OHC damage caused by noise exposure or ototoxic drugs. Temporary enhancement of OAEs may occur following noise exposure, and permanent enhancement of emissions has been associated with primary afferent dysfunction in the auditory system. This suggests that there are active adaptation processes in the cochlea exist that could potentially compensate for loss of afferent input. We have used the anti-cancer drug carboplatin to induce selective inner hair cell (IHC) lesions ..

View full abstract