Journal article

COCHLEAR FUNCTION AFTER SELECTIVE INNER HAIR CELL DEGENERATION INDUCED BY CARBOPLATIN

S TAKENO, RV HARRISON, D IBRAHIM, M WAKE, RJ MOUNT

HEARING RESEARCH | ELSEVIER SCIENCE BV | Published : 1994

Abstract

The ototoxicity of carboplatin, a second generation anti-cancer agent, was examined using the chinchilla as an animal model. In animals treated with a clinical therapeutic dose (400 mg/m2), the dominant degenerative change is to inner hair cells (IHCs). This is in sharp contrast to most other ototoxic agents, which damage primarily the outer hair cells (OHCs). Functional changes to the cochlea have been evaluated in carboplatin treated subjects by recording cochlear action potentials (CAP) and cochlear microphonics (CM); cochlear lesions were evaluated using scanning electron microscopy. In carboplatin treated animals, CAP thresholds to tone-pip stimuli were elevated in proportion to IHC dam..

View full abstract