Journal article

Carboplatin and hypofractionated accelerated radiotherapy: A dose escalation study of an outpatient chemoradiation schedule for squamous cell carcinoma of the head and neck

K Madhava, A Hartley, M Wake, JC Watkinson, J Glaholm

CLINICAL ONCOLOGY | ELSEVIER SCIENCE LONDON | Published : 2006

Abstract

AIM: To examine the feasibility and determine the maximum tolerated dose of outpatient carboplatin given with synchronous hypofractionated accelerated radiotherapy for squamous cell carcinoma of the head and neck (SCCHN). MATERIALS AND METHODS: Patients with stages II-IV SCCHN and unresected primary tumour were treated with synchronous carboplatin given in an outpatient setting on day 1 and day 21 in cohorts of three to six patients with incremental area under curve (AUC) factors commencing at 3.5. Grade 3 mucositis persisting for 4 weeks in two patients in a cohort was considered dose limiting. RESULTS: A total of 19 patients were enrolled and assessable for toxicity. All 19 patients comple..

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