Journal article
A review of the influence of mammographic density on breast cancer clinical and pathological phenotype
MS Shawky, CW Huo, MA Henderson, A Redfern, K Britt, EW Thompson
Breast Cancer Research and Treatment | SPRINGER | Published : 2019
Abstract
Purpose: It is well established that high mammographic density (MD), when adjusted for age and body mass index, is one of the strongest known risk factors for breast cancer (BC), and also associates with higher incidence of interval cancers in screening due to the masking of early mammographic abnormalities. Increasing research is being undertaken to determine the underlying histological and biochemical determinants of MD and their consequences for BC pathogenesis, anticipating that improved mechanistic insights may lead to novel preventative or treatment interventions. At the same time, technological advances in digital and contrast mammography are such that the validity of well-established..
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Funding Acknowledgements
The authors have received research grants from the University of Melbourne and St Vincent's Hospital Melbourne Foundation, Melbourne, Australia; the Translational Research Institute and Princess Alexandra Research Foundation, Brisbane, Australia; however, none have any financial relationship with these organisations.