Journal article
Elevated Serum Homocysteine Levels Have Differential Gender-Specific Associations with Motor and Cognitive States in Parkinson's Disease
MC Bakeberg, A Jefferson, M Riley, M Byrnes, S Ghosh, FL Mastaglia, MK Horne, S McGregor, R Stell, J Kenna, S Walters, D Hince, RS Anderton
Parkinson S Disease | HINDAWI LTD | Published : 2019
DOI: 10.1155/2019/3124295
Abstract
Background. Studies attempting to elucidate an association between homocysteine and symptom progression in Parkinson's disease (PD) have had largely discrepant findings. This study aimed to investigate elevated serum homocysteine levels and symptom progression in a cohort of PD patients. Methods. Serum homocysteine, folate, and vitamin B12 levels were measured in 205 people with PD and 78 age-matched healthy controls. People with Parkinson's disease underwent a battery of clinical assessments to evaluate symptom severity, including motor (MDS-UPDRS) and cognitive (ACE-R) assessments. Multivariate generalised linear models were created, controlling for confounding variables, and were used to ..
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Funding Acknowledgements
This study was supported by the Federal Cooperative Research Centre for Mental Health, the Perron Institute for Neurological and Translational Science, and the University of Notre Dame Australia. This research was carried out while MCB was in receipt of a Richard Walter Gibbon Medical Research Scholarship and an Australian Government Research Training Program Scholarship at the University of Western Australia.