HDL Phospholipids, but Not Cholesterol Distinguish Acute Coronary Syndrome From Stable Coronary Artery Disease
Peter J Meikle, Melissa F Formosa, Natalie A Mellett, Kaushala S Jayawardana, Corey Giles, David A Bertovic, Garry L Jennings, Wayne Childs, Medini Reddy, Andrew L Carey, Arul Baradi, Shane Nanayakkara, Andrew M Wilson, Stephen J Duffy, Bronwyn A Kingwell
Journal of the American Heart Association | Wiley | Published : 2019
Background Although acute coronary syndromes (ACS) are a major cause of morbidity and mortality, relationships with biologically active lipid species potentially associated with plaque disruption/erosion in the context of their lipoprotein carriers are indeterminate. The aim was to characterize lipid species within lipoprotein particles which differentiate ACS from stable coronary artery disease. Methods and Results Venous blood was obtained from 130 individuals with de novo presentation of an ACS (n=47) or stable coronary artery disease (n=83) before coronary catheterization. Lipidomic measurements (533 lipid species; liquid chromatography electrospray ionization/tandem mass spectrometry) ..View full abstract
Awarded by National Heart Foundation (NHF) of Australia
Awarded by National Health and Medical Research Council (NHMRC) of Australia
This work was supported by the National Heart Foundation (NHF) of Australia [G 12M 6453]; National Health and Medical Research Council (NHMRC) of Australia [APP103652; 1111170]; and the Operational Infrastructure Support Scheme of the Victorian State Government, Victoria, Australia. Professors Kingwell and Meikle are NHMRC research fellows.