Journal article

Ability of known susceptibility SNPs to predict colorectal cancer risk for persons with and without a family history

Mark A Jenkins, Aung K Win, James G Dowty, Robert J MacInnis, Enes Makalic, Daniel F Schmidt, Gillian S Dite, Mirosl Kapuscinski, Mark Clendenning, Christophe Rosty, Ingrid M Winship, Jon D Emery, Sibel Saya, Finlay A Macrae, Dennis J Ahnen, David Duggan, Jane C Figueiredo, Noralane M Lindor, Robert W Haile, John D Potter Show all

FAMILIAL CANCER | SPRINGER | Published : 2019

Abstract

Before SNP-based risk can be incorporated in colorectal cancer (CRC) screening, the ability of these SNPs to estimate CRC risk for persons with and without a family history of CRC, and the screening implications need to be determined. We estimated the association with CRC of a 45 SNP-based risk using 1181 cases and 999 controls, and its correlation with CRC risk predicted from detailed family history. We estimated the predicted change in the distribution across predefined risk categories, and implications for recommended screening commencement age, from adding SNP-based risk to family history. The inter-quintile risk ratio for colorectal cancer risk of the SNP-based risk was 3.28 (95% CI 2.5..

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Grants

Awarded by National Cancer Institute


Awarded by Australasian Colorectal Cancer Family Registry


Awarded by Ontario Familial Colorectal Cancer Registry


Awarded by Seattle Colorectal Cancer Family Registry


Awarded by Surveillance, Epidemiology and End Results (SEER) Program of the National Cancer Institute


Awarded by NIH


Awarded by National Health and Medical Research Council (NHMRC), Australia



Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

This work was supported by Grant U01 CA167551 from the National Cancer Institute and through cooperative agreements with the following Colon Cancer Family Registry sites: Australasian Colorectal Cancer Family Registry (U01 CA074778 and U01/U24 CA097735); Ontario Familial Colorectal Cancer Registry (U01/U24 CA074783); and Seattle Colorectal Cancer Family Registry (U01/U24 CA074794). The genome wide association studies (GWAS) were supported by Grants U01 CA 122839, R01 CA143237 and U19 CA148107. Additional support for case ascertainment was provided from the Surveillance, Epidemiology and End Results (SEER) Program of the National Cancer Institute to Fred Hutchinson Cancer Research Center (Control Nos. N01-CN-67009 and N01-PC-35142, and Contract No. HHSN2612013000121), the following U.S. state cancer registries: AZ, CO, MN, NC, NH, and by the Victorian Cancer Registry, Australia and the Ontario Cancer Registry, Canada. This work was also supported by grant R01CA170122 from NIH, and Centre for Research Excellence grant APP1042021 and Program Grant APP1074383 from the National Health and Medical Research Council (NHMRC), Australia. MAJ is a NHMRC Senior Research Fellow. AKW is a NHMRC Career Development Fellow. DDB is a NHMRC R.D. Wright Career Development Fellow and a University of Melbourne Research at Melbourne Accelerator Program (R@MAP) Senior Research Fellow. JLH is a NHMRC Senior Principal Research Fellow.