Journal article

Human Umbilical Cord Therapy Improves Long-Term Behavioral Outcomes Following Neonatal Hypoxic Ischemic Brain Injury

Tayla R Penny, Amy E Sutherland, Jamie G Mihelakis, Madison CB Paton, Yen Pham, Joohyung Lee, Nicole M Jones, Graham Jenkin, Michael C Fahey, Suzanne L Miller, Courtney A McDonald

FRONTIERS IN PHYSIOLOGY | FRONTIERS MEDIA SA | Published : 2019

Abstract

Background: Hypoxic ischemic (HI) insult in term babies at labor or birth can cause long-term neurodevelopmental disorders, including cerebral palsy (CP). The current standard treatment for term infants with hypoxic ischemic encephalopathy (HIE) is hypothermia. Because hypothermia is only partially effective, novel therapies are required to improve outcomes further. Human umbilical cord blood cells (UCB) are a rich source of stem and progenitor cells making them a potential treatment for neonatal HI brain injury. Recent clinical trials have shown that UCB therapy is a safe and efficacious treatment for confirmed cerebral palsy. In this study, we assessed whether early administration of UCB t..

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