Human Umbilical Cord Therapy Improves Long-Term Behavioral Outcomes Following Neonatal Hypoxic Ischemic Brain Injury
Tayla R Penny, Amy E Sutherland, Jamie G Mihelakis, Madison CB Paton, Yen Pham, Joohyung Lee, Nicole M Jones, Graham Jenkin, Michael C Fahey, Suzanne L Miller, Courtney A McDonald
FRONTIERS IN PHYSIOLOGY | FRONTIERS MEDIA SA | Published : 2019
Background: Hypoxic ischemic (HI) insult in term babies at labor or birth can cause long-term neurodevelopmental disorders, including cerebral palsy (CP). The current standard treatment for term infants with hypoxic ischemic encephalopathy (HIE) is hypothermia. Because hypothermia is only partially effective, novel therapies are required to improve outcomes further. Human umbilical cord blood cells (UCB) are a rich source of stem and progenitor cells making them a potential treatment for neonatal HI brain injury. Recent clinical trials have shown that UCB therapy is a safe and efficacious treatment for confirmed cerebral palsy. In this study, we assessed whether early administration of UCB t..View full abstract
This work was funded by Inner Wheel Australia and the Victorian Government's Operational Infrastructure Support Program. CM was supported by a National Health and Medical Research Council and Cerebral Palsy Alliance Australia Early Career Fellowship. SM was supported by a National Health and Medical Research Council Senior Research Fellowship.