Journal article

Improved Macaca fascicularis gene annotation reveals evolution of gene expression profiles in multiple tissues

Tao Tan, Lin Xia, Kailing Tu, Jie Tang, Senlin Yin, Lunzhi Dai, Peng Lei, Biao Dong, Hongbo Hu, Yong Fan, Yang Yu, Dan Xie

BMC Genomics | BMC | Published : 2018

Abstract

BACKGROUNDS: Macaca fascicularis (M. fascicularis) is a primate model organism that played important role in studying human health. It is vital to better understand the similarity and differences of gene regulation between M. fascicularis and human. Current comparative study of gene regulation between the two species are limited by low quality of gene annotation and lack of regulatory element data on M. fascicularis genome. RESULTS: In this study, we improved the M. fascicularis gene annotation with 57 gene expression data from multiple tissues and, more importantly, a manual curation procedure. The new annotation enabled us to map gene expression and identify gene location more accurately. ..

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Grants

Awarded by National Natural Science Foundation of China


Awarded by National Key Research and Development Program


Awarded by Natural Science Foundation of China


Awarded by Major Science and Technology Projects of Yunnan Province


Funding Acknowledgements

This work is supported by grants No. 91631111, 31571327, and 31771426 from National Natural Science Foundation of China (DX); the National Key Research and Development Program 2016YFA0502203 and National Natural Science Foundation of China No. 91740111 (HH); the National Key Research and Development Program 2017YFC0840100 (BD); Natural Science Foundation of China No. 81570060 (LD), and Major Science and Technology Projects of Yunnan Province 2017ZF028 (YY and TT).