Journal article

White matter hyperintensity quantification in large-scale clinical acute ischemic stroke cohorts - The MRI-GENIE study

Markus D Schirmer, Adrian Dalca, Ramesh Sridharan, Anne-Katrin Giese, Kathleen L Donahue, Marco J Nardin, Steven JT Mocking, Elissa C McIntosh, Petrea Frid, Johan Wasselius, John W Cole, Lukas Holmegaard, Christina Jern, Jordi Jimenez-Conde, Robin Lemmens, Arne G Lindgren, James F Meschia, Jaume Roquer, Tatjana Rundek, Ralph L Sacco Show all

NEUROIMAGE-CLINICAL | ELSEVIER SCI LTD | Published : 2019

Abstract

White matter hyperintensity (WMH) burden is a critically important cerebrovascular phenotype linked to prediction of diagnosis and prognosis of diseases, such as acute ischemic stroke (AIS). However, current approaches to its quantification on clinical MRI often rely on time intensive manual delineation of the disease on T2 fluid attenuated inverse recovery (FLAIR), which hinders high-throughput analyses such as genetic discovery. In this work, we present a fully automated pipeline for quantification of WMH in clinical large-scale studies of AIS. The pipeline incorporates automated brain extraction, intensity normalization and WMH segmentation using spatial priors. We first propose a brain e..

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Grants

Awarded by European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant


Awarded by NIH-NINDS


Awarded by NIH NIBIB NAC


Awarded by NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Funding Acknowledgements

This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 753896 (M.D. Schirmer). This study was supported by NIH-NINDS (MRI-GENIE: R01NS086905 - PI N. Rost, K23NS064052, R01NS082285 -N. Rost, SiGN: U01 NS069208 -J. Rosand, S. Kittner, R01NS059775, R01NS063925, R01NS082285, P50NS051343, R01NS086905, U01 NS069208 -O. Wu), NIH NIBIB NAC (P41EB015902 -P. Golland).