Journal article

Excessive Reactive Oxygen Species Inhibit IL-17A( ) gamma delta T Cells and Innate Cellular Responses to Bacterial Lung Infection

Desiree Anthony, Angelica Papanicolaou, Hao Wang, Huei Jiunn Seow, Eunice E To, Selcuk Yatmaz, Gary P Anderson, Odilia Wijburg, Stavros Selemidis, Ross Vlahos, Steven Bozinovski

ANTIOXIDANTS & REDOX SIGNALING | MARY ANN LIEBERT, INC | Published : 2019

Abstract

Aims: Excessive reactive oxygen species (ROS) are detrimental to immune cellular functions that control pathogenic microbes; however, the mechanisms are poorly understood. Our aim was to determine the immunological consequences of increased ROS levels during acute bacterial infection. Results: We used a model of Streptococcus pneumoniae (Spn) lung infection and superoxide dismutase 3-deficient (SOD3-/-) mice, as SOD3 is a major antioxidant enzyme that catalyses the dismutation of superoxide radicals. First, we observed that in vitro, macrophages from SOD3-/- mice generated excessive phagosomal ROS during acute bacterial infection. In vivo, there was a significant reduction in infiltrating ne..

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