Journal article

Polymicrobial interactions of Candida albicans and its role in oral carcinogenesis

Mohd Hafiz Arzmi, Stuart Dashper, Michael McCullough

JOURNAL OF ORAL PATHOLOGY & MEDICINE | WILEY | Published : 2019

Abstract

The oral microbiome is composed of microorganisms residing in the oral cavity, which are critical components of health and disease. Disruption of the oral microbiome has been proven to influence the course of oral diseases, especially among immunocompromised patients. Oral microbiome is comprised of inter-kingdom microorganisms, including yeasts such as Candida albicans, bacteria, archaea and viruses. These microorganisms can interact synergistically, mutualistically and antagonistically, wherein the sum of these interactions dictates the composition of the oral microbiome. For instance, polymicrobial interactions can improve the ability of C albicans to form biofilm, which subsequently incr..

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