Journal article

An appraisal of natural products active against parasitic nematodes of animals

Jose F Garcia-Bustos, Brad E Sleebs, Robin B Gasser

PARASITES & VECTORS | BMC | Published : 2019

Abstract

Here, the scientific and patent literature on the activities of purified natural compounds has been reviewed, with the aim of assessing their suitability as anthelmintic drug discovery starting points. Only compounds described as active against parasitic nematodes of animals or against the model nematode Caenorhabditis elegans have been analysed. Scientific articles published since 2010 and patents granted from 2000, both inclusive, have been included in this analysis. The results show a scarcity of novel chemical structures, a limited follow-up of compounds disclosed before 2010 and a bias towards the screening of plant products, almost to the exclusion of other sources, when microbial extr..

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Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

BES's research was supported by the National Health and Medical Research Council of Australia (Development Grant 1113712), Australian Cancer Research Foundation, the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. BES is a Corin Centenary Fellow. RBG's research was funded through grants from the Australian Research Council (ARC) and the National Health and Medical Research Council (NHMRC) of Australia, and Yourgene Bioscience Taiwan.