Are transplantable stem cells required for adult hematopoiesis?
Helen M McRae, Anne K Voss, Tim Thomas
Experimental Hematology | ELSEVIER SCIENCE INC | Published : 2019
Hematopoietic stem cells (HSCs) have been studied intensely for more than half a century. As a result, the properties of HSCs have become a paradigm of adult stem cell biology and function. The "classical" view of hematopoiesis suggests that the HSCs sit at the top of a hierarchy and that differentiation involves sequential production of multipotent and lineage committed progenitors with limited self-renewal capacity. This view of hematopoiesis is certainly valid after transplantation of HSCs, where, with appropriate support, a single HSC can regenerate the entire hematopoietic system of the recipient. However, it is not clear whether HSCs perform the same function during steady-state hemato..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by NHMRC
We apologize to the authors whose work on HSCs we were unable to include because of space constraints. This work was funded by the Australian Government through an Australian Postgraduate Award to HMM; National Health and Medical Research Council (NHMRC) Project Grants to AKV and TT (1084248, 1160518, 1161111); NHMRC Research Fellowships to TT (1003435) and AKV (575512); and an Independent Research Institutes Infrastructure Support (IRIIS) Scheme and a Victorian State Government OIS (Operational Infrastructure Support) grant.