DNA methylation changes following DNA damage in prostate cancer cells
Laura P Sutton, Sarah A Jeffreys, Jessica L Phillips, Phillippa C Taberlay, Adele F Holloway, Mark Ambrose, Ji-Hoon E Joo, Arabella Young, Rachael Berry, Marketa Skala, Kate H Brettingham-Moore
Epigenetics | TAYLOR & FRANCIS INC | Published : 2019
Many cancer therapies operate by inducing double-strand breaks (DSBs) in cancer cells, however treatment-resistant cells rapidly initiate mechanisms to repair damage enabling survival. While the DNA repair mechanisms responsible for cancer cell survival following DNA damaging treatments are becoming better understood, less is known about the role of the epigenome in this process. Using prostate cancer cell lines with differing sensitivities to radiation treatment, we analysed the DNA methylation profiles prior to and following a single dose of radiotherapy (RT) using the Illumina Infinium HumanMethylation450 BeadChip platform. DSB formation and repair, in the absence and presence of the DNA ..View full abstract
Awarded by Cancer Council Tasmania Michael Johns in Memoriam Research Grant Award
This work was funded by the University of Tasmania Research Enhancement Grant Scheme and The Cancer Council Tasmania Michael Johns in Memoriam Research Grant Award (B0023757).