Journal article

Pathophysiological role of respiratory dysbiosis in hospital-acquired pneumonia

A Roquilly, A Torres, JA Villadangos, MG Netea, R Dickson, B Becher, K Asehnoune

The Lancet Respiratory Medicine | ELSEVIER SCI LTD | Published : 2019


Hospital-acquired pneumonia is a major cause of morbidity and mortality. The incidence of hospital-acquired pneumonia remains high globally and treatment can often be ineffective. Here, we review the available data and unanswered questions surrounding hospital-acquired pneumonia, discuss alterations of the respiratory microbiome and of the mucosal immunity in patients admitted to hospital, and explore potential approaches to stratify patients for tailored treatments. The lungs have been considered a sterile organ for decades because microbiological culture techniques had shown negative results. Culture-independent techniques have shown that healthy lungs harbour a diverse and dynamic ecosyst..

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Funding Acknowledgements

The Review was funded by University Hospital of Nantes. The institutional funds used for this Review had no role in the design or conduct of the study, the data analysis, the writing of the manuscript or in the decision to submit the manuscript.