Journal article

Inhibition of apoptosis signal-regulating kinase 1 ameliorates left ventricular dysfunction by reducing hypertrophy and fibrosis in a rat model of cardiorenal syndrome

Feby Savira, Bing H Wang, Amanda J Edgley, Beat M Jucker, Robert N Willette, Henry Krum, Darren J Kelly, Andrew R Kompa

International Journal of Cardiology | Elsevier | Published : 2020

Abstract

BACKGROUND: Cardiorenal syndrome (CRS) is a major health burden worldwide in need of novel therapies, as current treatments remain suboptimal. The present study assessed the therapeutic potential of apoptosis signal-regulating kinase 1 (ASK1) inhibition in a rat model of CRS. METHODS: Adult male Sprague-Dawley rats underwent surgery for myocardial infarction (MI) (week 0) followed by 5/6 subtotal nephrectomy (STNx) at week 4 to induce to induce a combined model of heart and kidney dysfunction. At week 6, MI + STNx animals were randomized to receive either 0.5% carboxymethyl cellulose (Vehicle, n = 15, Sham = 10) or G226 (15 mg/kg daily, n = 11). Cardiac and renal function was assessed by ..

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Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

This research was supported by National Health and Medical Research Council of Australia (Program Grants 1092642 and Project Grant 1087355). FS is supported by Monash International Postgraduate Research Scholarship and Monash Graduate Scholarship.