Tissue-resident memory T cells orchestrate tumour-immune equilibrium
Simone L Park, Laura K Mackay, Jason Waithman, Thomas Gebhardt
CELL STRESS | SHARED SCIENCE PUBLISHERS OG | Published : 2019
The immune system can prevent tumour development by engaging in a process termed cancer immunosurveillance, during which immune cells such as T cells restrict tumour growth either by completely eradicating cancer cells in a process of 'elimination' or by suppressing cancer cell outgrowth by establishing a state of tumour-immune 'equilibrium'. Most cancers develop within epithelial layers of tissues but circulating T cells are largely excluded from these epithelial tissue compartments in the absence of infection or overt inflammation. In contrast, CD8+ tissue-resident memory T (TRM) cells reside permanently within epithelial layers of peripheral tissues without recirculating in blood. Accumul..View full abstract
S.L.P is a Cancer Council Victoria Postdoctoral Fellow, J.W. is a Cancer Council of Western Australia Fellow, and L.K.M and T.G. are Senior Medical Research Fellows supported by the Sylvia and Charles Viertel Charitable Foundation.