Identification of HIV transmitting CD11c human epidermal dendritic cells.
Kirstie M Bertram, Rachel A Botting, Heeva Baharlou, Jake W Rhodes, Hafsa Rana, J Dinny Graham, Ellis Patrick, James Fletcher, Toby M Plasto, Naomi R Truong, Caroline Royle, Chloe M Doyle, Orion Tong, Najla Nasr, Laith Barnouti, Mark P Kohout, Andrew J Brooks, Michael P Wines, Peter Haertsch, Jake Lim Show all
Nat Commun | Published : 2019
Langerhans cells (LC) are thought to be the only mononuclear phagocyte population in the epidermis where they detect pathogens. Here, we show that CD11c+ dendritic cells (DCs) are also present. These cells are transcriptionally similar to dermal cDC2 but are more efficient antigen-presenting cells. Compared to LCs, epidermal CD11c+ DCs are enriched in anogenital tissues where they preferentially interact with HIV, express the higher levels of HIV entry receptor CCR5, support the higher levels of HIV uptake and replication and are more efficient at transmitting the virus to CD4 T cells. Importantly, these findings are observed using both a lab-adapted and transmitted/founder strain of HIV. We..View full abstract
Awarded by NIH HHS
Awarded by NIAID NIH HHS
Awarded by Department of Health | National Health and Medical Research Council (NHMRC)