Journal article

Genomics of the Pathogenic Clostridia

Robert J Moore, Jake A Lacey

Microbiology Spectrum | AMER SOC MICROBIOLOGY | Published : 2019

Abstract

Whole-genome sequences are now available for all the clinically important clostridia and many of the lesser or opportunistically pathogenic clostridia. The complex clade structures of C. difficile, C. perfringens, and the species that produce botulinum toxins have been delineated by whole-genome sequence analysis. The true clostridia of cluster I show relatively low levels of gross genomic rearrangements within species, in contrast to the species of cluster XI, notably C. difficile, which have been found to have very plastic genomes with significant levels of chromosomal rearrangement. Throughout the clostridial phylotypes, a large proportion of the strain diversity is driven by the acquisit..

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University of Melbourne Researchers