Genomic diversity of necrotic enteritis-associated strains of Clostridium perfringens: a review
Jake A Lacey, Priscilla A Johanesen, Dena Lyras, Robert J Moore
AVIAN PATHOLOGY | TAYLOR & FRANCIS LTD | Published : 2016
The investigation of genomic variation between Clostridium perfringens isolates from poultry has been an important tool to enhance our understanding of the genetic basis of strain pathogenicity and the epidemiology of virulent and avirulent strains within the context of necrotic enteritis (NE). The earliest studies used whole genome profiling techniques such as pulsed-field gel electrophoresis to differentiate isolates and determine their relative levels of relatedness. DNA sequencing has been used to investigate genetic variation in (a) individual genes, such as those encoding the alpha and NetB toxins; (b) panels of housekeeping genes for multi-locus sequence typing and (c) most recently w..View full abstract
Robert Moore gratefully acknowledges ongoing support from the Poultry Cooperative Research Centre, established and supported under the Australian Government's Cooperative Research Centres Program.