Journal article

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Darina Czamara, Goekcen Eraslan, Christian M Page, Jari Lahti, Marius Lahti-Pulkkinen, Esa Hamalainen, Eero Kajantie, Hannele Laivuori, Pia M Villa, Rebecca M Reynolds, Wenche Nystad, Siri E Haberg, Stephanie J London, Kieran J O'Donnell, Elika Garg, Michael J Meaney, Sonja Entringer, Pathik D Wadhwa, Claudia Buss, Meaghan J Jones Show all

Nature Communications | NATURE PUBLISHING GROUP | Published : 2019

University of Melbourne Researchers

Grants

Awarded by European Commission


Awarded by Ministry of Education and Research, NIH/NIEHS


Awarded by Ministry of Education and Research, NIH/NINDS


Awarded by Intramural Research Program of the NIH, National Institute of Environmental Health Sciences


Awarded by Norwegian Research Council/BIOBANK


Awarded by Research Council of Norway through its Centres of Excellence funding scheme


Awarded by Bill and Melinda Gates Foundation


Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health (NICHD)


Awarded by German Federal Ministry of Education and Research through the Research Consortium Integrated Network IntegraMent under e:Med Programme (NSM)


Awarded by European Research Area Network (ERA Net) Neuron grant


Awarded by National Institutes of Health grant


Awarded by NIH


Funding Acknowledgements

We want to thank Susanne Sauer and Maik Kodel for their technical assistance and Jessica Keverne for language editing. We thank all mothers who took part in the on-going PREDO study. We are grateful to all the families in Norway who participate in the ongoing MoBa cohort study. We thank the Drakenstein Child Health Study staff, and the clinical and administrative staff of the Western Cape Government Department of Health at Paarl Hospital and at the clinics for support of the Study. We also thank our collaborators and students. Finally, we thank all mothers and children enroled in the Drakenstein Child Health Study. We thank the research participants and employees of 23andMe, Inc. for their contribution to this study. This work was supported by the Academy of Finland (E.K., H.L., K.R., and J.L.); University of Helsinki Research Funds (J.L., M.L.P., and H.L.), British Heart Foundation (RMR); Tommy's (RMR); European Commission (EK, KR, Horizon 2020 Award SC1-2016-RTD-733280 RECAP); NorFace DIAL (E.K., KR PremLife); Foundation for Pediatric Research (E.K.); Juho Vainio Foundation (E.K.); Novo Nordisk Foundation (E.K.); Signe and Ane Gyllenberg Foundation (E.K., K.R.); Sigrid Juselius Foundation (E.K.); Finnish Medical Foundation (H.L.); Jane and Aatos Erkko Foundation (H.L.); Paivikki and Sakari Sohlberg Foundation (H.L., P.M.V.); the Clinical Graduate school in Pediatrics and Obstetrics/Gynaecology in University of Helsinki (P.M.V.). The Norwegian Mother and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research, NIH/NIEHS (contract no N01-ES-75558), NIH/NINDS (grant no. 1 UO1 NS 047537-01 and grant no. 2 UO1 NS 047537-06A1). For this work, MoBa 1 and 2 were supported by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences (Z01-ES-49019) and the Norwegian Research Council/BIOBANK (grant no 221097). This work was also partly supported by the Research Council of Norway through its Centres of Excellence funding scheme, project number 262700. The Drakenstein Child Health Study is supported by the Bill and Melinda Gates Foundation (OPP 1017641); with additional support for this work from the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health (NICHD) under Award Number R21HD085849; and the Fogarty International Center (FIC). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Additional support for H.J.Z., D.J.S. and N.K., and for research reported in this publication was by the South African Medical Research Council (SAMRC); N.K. receives support from the SAMRC under a Self-Initiated Research Grant. The views and opinions expressed are those of the authors and do not necessarily represent the official views of the SAMRC. This work was also funded by the German Federal Ministry of Education and Research through the Research Consortium Integrated Network IntegraMent (grant 01ZX1314H) under the auspices of the e:Med Programme (NSM). The UCI cohort was supported by a European Research Area Network (ERA Net) Neuron grant (01EW1407A, CB) and National Institutes of Health grant (R01 HD-060628, CB) as well as NIH grant R01 MH-105538 (PDW). This work was also funded by the Canadian Institute for Advanced Research, Child and Brain Development Program, Toronto, ON, Canada (KJOD).