Pioglitazone Therapy in Patients With Stroke and Prediabetes A Post Hoc Analysis of the IRIS Randomized Clinical Trial

J David Spence; Catherine M Viscoli; Silvio E Inzucchi; Jennifer Dearborn-Tomazos; Gary A Ford; Mark Gorman; Karen L Furie; Anne M Lovejoy; Lawrence H Young; Walter N Kernan; Christopher Bladin; Stephen Davis; Tissa Wijeratne; Christopher Levi; Mark Parsons; Amy Brodtmann; Steven Ng; John Archer; Candice Delcourt; Toni R Winder; Leo Berger; Greenfield Park; Jean-Martin Boulanger; Richard K Chan; J David Spence; Andre Durocher; Notre-Dame Montreal; Ariane Mackey; Steve Verreault; Jeffrey Minuk; Andrew M Penn; Ashfaq Shuaib; Robert Cote; Daniel Selchen; Neville Bayer; Margaret Sweet; Salim Malik; Grant Stotts; Bernd Griewing; Hassan Soda; Renate Weinhar; Joerg Berrouschot; Anett Stoll; Otto W Witte; Albrecht Guenther; Ulf Bodechtel; Ulf Schminke; Carsten Hobohm; Andreas Hetzel; Johann Lambeck; Katja E Wartenberg; Hagen Huttner; Ralf Dittrich; Darius G Nabavi; Klaus Groeschel; Gotz Thomalla; M Rosenkranz; Sebastian Jander; Andreas Meisel; Albert Ludolph; Katharina Althaus; R Huber; Matthias Rosenbaum; Pasquale Fonzetti; James D Fleck; Adrian J Goldszmidt; Andrei V Alexandrov; James H Halsey; Robert Hart; Justin A Sattin; Sandeep Kumar; Diane Book; Michel Torbey; James J Poock; Molly K King; Glenn D Graham; Gene Yong Sung; Thomas Mirsen; Alexander W Dromerick; Andreas D Runheim; Christy M Jackson; Eliahu Feen; Raymond K Reichwein; Michael F Waters; Colum Amory; Gary L Bernardini; Rodney D Bell; B Franklin Diamond; Daniel M Rosenbaum; David Palestrant; Alan Z Segal; Ronald L Schwartz; Panayiotis Mitsias; Jeffrey Kramer; David Robbins; Brian Silver; J Donald Easton; Edward Feldmann; Marilyn M Rymer; Joyce Dorssom; Latisha Ali; Bruce Ovbiagele; Howard S Kirshner; Walter N Kernan; L Brass; K Furie; Anne M Lovejoy; R Horwitz; Silvio E Inzucchi; Catherine M Viscoli; Lawrence H Young; Kathleen Burger; Harold P Adams; Gary Ford; Peter Guarino; Peter N Peduzzi; Peter Ringleb; Gregory Schwartz; Phillip B Gorelick; Eugene J Barrett; Mark L Dyken; Richard W Nesto; William T Longstreth; Dejuran Richardson; John O'Leary; B Zhou; Osama Abdelghany; Sandra L Alfono; Lauren Golden; Dan Lorber; Erin W Hofstatter; Frederick S Ling; J Dawn Abbott; Jeptha P Curtis; JoAnne M Foody; Daniel Jacoby; Daniel M Kolansky; Steven Pfau; John M Lasala; Mary T Korytkowski; Sam Engel; Faramarz Ismail-Beigi; David McCulloch; Richard E Pratley; Paulos Berhanu; Enrique Caballero; Sam Dagogo-Jack; Mark H Schutta; Andy Haims; Karl Insogna; Dieter Lindskog; Ron Adelman; Scott Kasner; Joseph P Broderick; Mark J Alberts; Michael D Walker; John B Buse; Lloyd Chambless; David Faxon; Jennifer K Pary; Robin Conwit; Claudia Scala Moy; Scott Janis; Laurie Gutmann; Barbara Radziszewska

Journal article

Pioglitazone Therapy in Patients With Stroke and Prediabetes A Post Hoc Analysis of the IRIS Randomized Clinical Trial

J David Spence, Catherine M Viscoli, Silvio E Inzucchi, Jennifer Dearborn-Tomazos, Gary A Ford, Mark Gorman, Karen L Furie, Anne M Lovejoy, Lawrence H Young, Walter N Kernan, Christopher Bladin, Stephen Davis, Tissa Wijeratne, Christopher Levi, Mark Parsons, Amy Brodtmann, Steven Ng, John Archer, Candice Delcourt, Toni R Winder Show all

JAMA NEUROLOGY | AMER MEDICAL ASSOC | Published : 2019

DOI: 10.1001/jamaneurol.2019.0079

Abstract

IMPORTANCE: In the Insulin Resistance Intervention After Stroke (IRIS) randomized clinical trial, pioglitazone, an insulin-sensitizing agent, reduced the risk for recurrent stroke or myocardial infarction (MI) among patients with insulin resistance. However, insulin resistance is not commonly measured in clinical practice. OBJECTIVE: To analyze the effects of pioglitazone in patients with good adherence as well as intention-to-treat effects of pioglitazone in patients with prediabetes in the IRIS trial. DESIGN, SETTING, AND PARTICIPANTS: The IRIS trial was a randomized multicenter clinical trial in patients with prior stroke or transient ischemic attack as well as insulin resistance but not ..

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University of Melbourne Researchers

Stephen Davis Author

Tissa Wijeratne Author

Mark Parsons Author

Amy Brodtmann Author

Grants

Awarded by National Institute of Neurological Disorders and Stroke

Funding Acknowledgements

The IRIS trial was supported by a grant (U01NS044876) from the National Institute of Neurological Disorders and Stroke. Takeda Pharmaceuticals International Inc donated pioglitazone and matching placebo for the trial and had the right to a delay of up to 6 weeks before submission of the paper for patent purposes.