Pioglitazone Therapy in Patients With Stroke and Prediabetes A Post Hoc Analysis of the IRIS Randomized Clinical Trial

J David Spence; Catherine M Viscoli; Silvio E Inzucchi; Jennifer Dearborn-Tomazos; Gary A Ford; Mark Gorman; Karen L Furie; Anne M Lovejoy; Lawrence H Young; Walter N Kernan; Christopher Bladin; Stephen Davis; Tissa Wijeratne; Christopher Levi; Mark Parsons; Amy Brodtmann; Steven Ng; John Archer; Candice Delcourt; Toni R Winder; Leo Berger; Greenfield Park; Jean-Martin Boulanger; Richard K Chan; J David Spence; Andre Durocher; Notre-Dame Montreal; Ariane Mackey; Steve Verreault; Jeffrey Minuk; Andrew M Penn; Ashfaq Shuaib; Robert Cote; Daniel Selchen; Neville Bayer; Margaret Sweet; Salim Malik; Grant Stotts; Bernd Griewing; Hassan Soda; Renate Weinhar; Joerg Berrouschot; Anett Stoll; Otto W Witte; Albrecht Guenther; Ulf Bodechtel; Ulf Schminke; Carsten Hobohm; Andreas Hetzel; Johann Lambeck; Katja E Wartenberg; Hagen Huttner; Ralf Dittrich; Darius G Nabavi; Klaus Groeschel; Gotz Thomalla; M Rosenkranz; Sebastian Jander; Andreas Meisel; Albert Ludolph; Katharina Althaus; R Huber; Matthias Rosenbaum; Pasquale Fonzetti; James D Fleck; Adrian J Goldszmidt; Andrei V Alexandrov; James H Halsey; Robert Hart; Justin A Sattin; Sandeep Kumar; Diane Book; Michel Torbey; James J Poock; Molly K King; Glenn D Graham; Gene Yong Sung; Thomas Mirsen; Alexander W Dromerick; Andreas D Runheim; Christy M Jackson; Eliahu Feen; Raymond K Reichwein; Michael F Waters; Colum Amory; Gary L Bernardini; Rodney D Bell; B Franklin Diamond; Daniel M Rosenbaum; David Palestrant; Alan Z Segal; Ronald L Schwartz; Panayiotis Mitsias; Jeffrey Kramer; David Robbins; Brian Silver; J Donald Easton; Edward Feldmann; Marilyn M Rymer; Joyce Dorssom; Latisha Ali; Bruce Ovbiagele; Howard S Kirshner; Walter N Kernan; L Brass; K Furie; Anne M Lovejoy; R Horwitz; Silvio E Inzucchi; Catherine M Viscoli; Lawrence H Young; Kathleen Burger; Harold P Adams; Gary Ford; Peter Guarino; Peter N Peduzzi; Peter Ringleb; Gregory Schwartz; Phillip B Gorelick; Eugene J Barrett; Mark L Dyken; Richard W Nesto; William T Longstreth; Dejuran Richardson; John O'Leary; B Zhou; Osama Abdelghany; Sandra L Alfono; Lauren Golden; Dan Lorber; Erin W Hofstatter; Frederick S Ling; J Dawn Abbott; Jeptha P Curtis; JoAnne M Foody; Daniel Jacoby; Daniel M Kolansky; Steven Pfau; John M Lasala; Mary T Korytkowski; Sam Engel; Faramarz Ismail-Beigi; David McCulloch; Richard E Pratley; Paulos Berhanu; Enrique Caballero; Sam Dagogo-Jack; Mark H Schutta; Andy Haims; Karl Insogna; Dieter Lindskog; Ron Adelman; Scott Kasner; Joseph P Broderick; Mark J Alberts; Michael D Walker; John B Buse; Lloyd Chambless; David Faxon; Jennifer K Pary; Robin Conwit; Claudia Scala Moy; Scott Janis; Laurie Gutmann; Barbara Radziszewska

Journal article

Pioglitazone Therapy in Patients With Stroke and Prediabetes A Post Hoc Analysis of the IRIS Randomized Clinical Trial

J David Spence, Catherine M Viscoli, Silvio E Inzucchi, Jennifer Dearborn-Tomazos, Gary A Ford, Mark Gorman, Karen L Furie, Anne M Lovejoy, Lawrence H Young, Walter N Kernan, Christopher Bladin, Stephen Davis, Tissa Wijeratne, Christopher Levi, Mark Parsons, Amy Brodtmann, Steven Ng, John Archer, Candice Delcourt, Toni R Winder Show all

JAMA Neurology | AMER MEDICAL ASSOC | Published : 2019

DOI: 10.1001/jamaneurol.2019.0079

University of Melbourne Researchers

Tissa Wijeratne Author

Amy Brodtmann Author Medicine - Austin Health

John Archer Author Medicine - Austin Health

Stephen Davis Author Medicine - Royal Melbourne Hospital

Grants

Awarded by National Institute of Neurological Disorders and Stroke

Funding Acknowledgements

The IRIS trial was supported by a grant (U01NS044876) from the National Institute of Neurological Disorders and Stroke. Takeda Pharmaceuticals International Inc donated pioglitazone and matching placebo for the trial and had the right to a delay of up to 6 weeks before submission of the paper for patent purposes.