Early T-BET Expression Ensures an Appropriate CD8( ) Lineage-Specific Transcriptional Landscape after Influenza A Virus Infection
Julia E Prier, Jasmine Li, Linden J Gearing, Moshe Olshansky, Xavier YX Sng, Paul J Hertzog, Stephen J Turner
The Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2019
Virus infection triggers large-scale changes in the phenotype and function of naive CD8+ T cells, resulting in the generation of effector and memory T cells that are then critical for immune clearance. The T-BOX family of transcription factors (TFs) are known to play a key role in T cell differentiation, with mice deficient for the TF T-BET (encoded by Tbx21) unable to generate optimal virus-specific effector responses. Although the importance of T-BET in directing optimal virus-specific T cell responses is accepted, the precise timing and molecular mechanism of action remains unclear. Using a mouse model of influenza A virus infection, we demonstrate that although T-BET is not required for ..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) of Australia
This work was supported by grants from the National Health and Medical Research Council (NHMRC) of Australia (Program Grant 5671222 and Project Grant APP1003131 [both to S. J. T.]). S.J.T. is supported by an NHMRC principal research fellowship. J.E.P. is supported by an Australian postgraduate award.